Cipro iv ciprofloxacin dose, indications, adverse effects. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is. The aim of stockleys drug interactions is to inform busy doctors, pharma cists, surgeons. Theophylline, also known as 1,3dimethylxanthine, is a methylxanthine drug used in therapy for respiratory diseases such as chronic obstructive pulmonary disease copd and asthma under a variety of brand names. Theophylline uniphyl and theo24 side effects, dosage. A 70yearold man similarly developed theophylline toxicity,with theophylline levels of about 32 mgl reference range 10 to 20 mgl, when fluvoxamine was added. Pharmacokinetic interactions between theophylline and. Theophylline drug interactions can alter the level of theophylline in your blood or make some drugs less effective, among other things. Fall of total drug level accommodates rise in free fraction % freetotal concentration with minimal pharmacodynamic effect.
Theophylline is the generic name for the prescription drugs uniphyl in canada and theo24. Theophylline definition of theophylline by medical dictionary. This drug drug interaction may cause you to experience an unexpected side effect. Theophylline may also be used for purposes not listed in this medication guide. Pharmacokinetic interactions between theophylline and other. Fluoxetine hydrochloride and theophylline drug interactions. If you are taking these drugs together, your healthcare provider may need to adjust your theophylline dosage. Theophylline, anhydrous oral tablet, extended release 24 hour drug summary. Effect of the addition of ciprofloxacin on theophylline. Lanophyllin intravenous interactions with other medication. Drug interactions are reported among people who take levofloxacin and theophylline together.
Pdr drug summaries are concise pointofcare prescribing, dosing and administering information to help phsyicans more efficiently and accurately prescribe in their practice pdr s drug summaries are available free of charge and serve as a great resource for us based mds, dos, nps and pas in patient practice. Theophylline, anhydrous oral tablet, extended release 24 hour. Dailymed theophylline anhydrous theophylline tablet. Johns wort without first talking with your healthcare provider. Drug interactions with erythromycin oral and theophylline oral. Cs medications are substrates of cyp1a2 acetaminophen, caffeine, cyclobenzaprine, diazepam, duloxetine. Drug interactions are reported among people who take theophylline and alcohol together. Levofloxacin and theophylline drug interactions a study. Many drugs have been found to increase or decrease the clearance of theophylline, probably by interaction with one or more of the variants of the cytochrome p450 drug metabolising system. If you are taking these drugs together, your healthcare provider should monitor the level of theophylline in your blood and adjust your theophylline dosage as necessary. Drug interactions with phenytoin are a frequent occurrence, although their clinical relevance has often been overemphasised. Alcohol, quinidine, and warfarin may potentially cause drug interactions with phenytoin.
Whatever the mechanism, the interaction may be sufficient to necessitate adjustment of the theophylline dosage. Use the search field above to look up prescription or otc drugs, and herbal supplements. Theophylline drug, uses, dose, tablets, side effects. When theophylline is given with enteral tube feedings, blood levels may be decreased due to interference with its absorption. Online store how to order refill order contact us faqs. To reduce the risk of developing potentially dangerous drug interactions with theophylline, you should talk with your healthcare provider or pharmacist about any theophylline interactions that may apply to you. Theophylline complete drug information, side effects and. Advanced search provides a powerful interface for searching the database. The drug is metabolised in the liver by cytochrome p450 isoenzymes, principally cyp1a2, to demethylated and hydroxylated products. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. All interactions with theophylline slophyllin, theodur coadministered drug dose of drug dose of theophylline effect on drug levels effect on theophylline levels potential clinical effects mechanism of interaction management.
Drug interactions with theophylline may demand dosage. Find medication information including related drug classes, side effects, patient statistics and answers to frequently asked questions. This study is created by ehealthme based on reports of 12 people who take fluoxetine hydrochloride and theophylline from food and drug administration fda, and is updated regularly. Theophylline elixophyllin, theo24 is a bronchodilator prescribed for the treatment of asthma and other airway conditions. To minimize potential for interaction, you may interrupt the feeding for one hour before and one hour after the theophylline dose. Seek medical attention if your breathing problems get worse. Theophylline oral interactions with other medication. Do not start, stop or change the dosage of any medicine before checking with them first. Theophylline, ephedrine, and phenobarbital advanced. In a randomized crossover sequence, subjects received theophylline 5 mgkg on day 6 of therapy with cimetidine 2400 mgd, ciprofloxacin 1 gd, both drugs, or while drug free. A blood sample should usually be taken 46 hours after an oral dose of a modifiedrelease preparation sampling times may varyconsult local guidelines. Oxcarbazepine has fewer drug interactions than carbamazepine, and gabapentin has one, a.
Most common drug drug interactions marengoni study. Caffeinecontaining herbs such as cola nut, guarana, mate. Theophylline free drug price comparison free rx coupons. Although we attempt to provide accurate and uptodate information, no guarantee is made to that effect.
Selected herbdrug interactions university of michigan. You can build up queries that support a wide range of conditions and predicates. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. As a member of the xanthine family, it bears structural and pharmacological similarity to theobromine and caffeine, and is readily found in nature, being present in tea camellia. Please check with a physician if you have health questions or concerns. A drug interaction is an interaction between a drug and some other substance, such as another drug or a certain type of food, which prevents the drug from. Drug interactions checker medscape drug reference database. See what the interactions are and for which people. Interactions between lanophyllin oral and theophyllines. This study is created by ehealthme based on reports of 186 people who take levofloxacin and theophylline from food and drug administration fda, and is. A bronchodilator, aminophylline is a derivative of theophylline. During treatment with theophylline, do not start or stop taking st. The drug aminophylline differs somewhat in its structure from theophylline in that it contains ethylenediamine, as well as more molecules of water. Both aminophylline and theophylline are methylxanthines and are derived from the group called xanthines.
The most common types of seizures are generalized and partial seizures with secondary generalization,151,152 but status epilepticus can occur in approximately 30% of patients. Evaluated prevalence and characteristics of adrs from drug interactions 1014 adrs analyzed 912 of the adrs had direct drug interactions 31% considered major most were hemorrhages 54% warfarin was most common drug involved. Taking theophylline extendedrelease tablets immediately after ingesting a high fat content meal 45 g fat, 55 g carbohydrates, 28 g protein, 789 calories may result in a somewhat higher c max and delayed t max and a somewhat greater extent of absorption when compared to taking it in the fasting. Dailymed theophylline theophylline anhydrous solution. Theophylline and alcohol drug interactions a study of fda. Applied pharmaceutical practice christopher a langley senior lecturer in pharmacy practice aston university school of pharmacy, birmingham, uk and dawn belcher teaching fellow, pharmacy practice, aston university school of pharmacy, birmingham, uk london chicago app prelims 22808 1.
Plasmatheophylline concentration is measured 5 days after starting oral treatment and at least 3 days after any dose adjustment. National institutes of healthfunded general clinical research center. Theophylline interacts with a wide variety of drugs. Pdf amnesic syndrome after theophylline associated seizures. Theophylline is an oral medication used to treat asthma and other lung diseases. To get started, click the add search condition button to select your first field. Drug interactions theophylline interacts with a wide variety of drugs. Selected herb drug interactions herb common use may interact with potential effect alfalfa medicago sativa multiple, including treatment of arthritis, asthma, dyspepsia, hyperlipidemia, and diabetes anticoagulants 1,2 alfalfa contains coumarin constituents and vitamin k.
Theophylline interactions learning article pharmaceutical. Drug interactions with theophylline may demand dosage adjustment. Do not take theophylline if you are addict of tobacco, cannabis and alcohol. Before using this medication, tell your doctor or pharmacist of all prescription and. Somophyllin interactions somophyllin interacts with a wide variety of drugs. This study is created by ehealthme based on reports of 26 people who take theophylline and alcohol from food and drug administration fda, and is updated regularly. Levofloxacin and theophylline drug interactions a study of. Many drugs have been found to increase or decrease the clearance of theophylline, probably by interaction with one or more of the variants of the cytochrome p450 drug. Drug interactions with phenytoin nervous system home page. Dailymed theophylline theophylline, anhydrous capsule. Since up to 90% of a theophylline dose is biotransformed, drugs influencing microsomal enzyme systems in the liver may affect the elimination of theophylline. Johns wort can decrease the level of theophylline in your blood, perhaps making it less effective. Theophylline is now usually used as an addon therapy in asthma patients not well controlled on inhaled.
Common drug interactions boca raton regional hospital. Drug interactions are reported among people who take fluoxetine hydrochloride and theophylline together. Evolution of drug metabolism as a science richard tecwyn williams great britain 1942, worked on the metabolism on tnt with regard to toxicity in munitions workers. Learn who its for, how it works, its side effects, warnings, and more. This page on the emedtv web site explains what other drugs may cause phenytoin interactions and describes the possible risks of combining them with phenytoin. Taking theophylline with propranolol can greatly increase the level of theophylline in your blood, which can cause dangerous side effects. Drug interactions may change how your medications work or increase your risk for serious side effects. Taking theophylline with certain antibiotics can increase the level of theophylline in your blood, which can cause dangerous side effects. Theophylline prescription drug information, interactions. Dec, 2012 since up to 90% of a theophylline dose is biotransformed, drugs influencing microsomal enzyme systems in the liver may affect the elimination of theophylline.
Theophylline, anhydrous oral tablet, extended release drug. Theophylline, anhydrous oral tablet, extended release drug summary. Many drugs interact with theophylline by inhibiting or potentiating its metabolism by cyp1a2 see commonlyused drugs that interact with theophylline. It requires monitoring of drug levels so is not often used anymore except in difficult to manage cases. This may reduce the effectiveness of the medication. We would like to show you a description here but the site wont allow us. Theophylline is an older drug used to treat asthma or copd, it works as a bronchodilator.
Theophylline generic drug search results polarmeds. At least one manufacturer suggests dosage of approximately 0. To include fields in the results that you dont want to search, click add display field below. Learn about theophylline from patients first hand experiences and trusted online health resources, including dosage, side effects and interactions. Latest news democratic rep says hydroxychloroquine, trump helped save her life amid covid19 fight. Now in its twelfth edition, stockleys drug interactions is still the most comprehensive and authoritative international source of drug interaction information.
Amnesic syndrome after theophylline associated seizures. Theophylline interactions bnf content published by nice. Drug interactions with fluvoxamine oral and theophylline oral. Probably the most important of such interactions are those resulting in inhibition of phenytoin metabolism. Drug interactions a drug may affect the activity of another by altering its metabolism. Theophylline is a widely used bronchodilator and a very potent central nervous system cns stimulant. Pharmacokinetic interactions between theophylline and other medication part i. All interactions with theophylline slophyllin, theodur coadministered drug dose of drug dose of theophylline.
It naturally occurs in black tea, and is degraded by the liver to caffeine. Before using theophylline, ephedrine, and phenobarbital. C are at risk for cytochrome cyp p450 drug interactions when they are admitted to or discharged from a smoke free facility. Refer to precautions, drug interactions for information regarding table.
Products containing theophylline, ephedrine, and phenobarbital were withdrawn from the u. Never use theophylline in larger amounts, or for longer than prescribed. Whatever the mechanism, the interaction may be sufficient to necessitate adjustment of the theophylline dosage, preferably. Theophylline toxicity, mainly iatrogenic, can cause seizures in patients without known underlying epilepsy. The molecular formula of anhydrous theophylline is c 7 h 8 n 4 o 2 with a molecular weight of 180. Theophylline comes as an extendedrelease longacting tablet, extendedrelease capsule, and a solution liquid to take by mouth. See what others have said about theophylline, including the effectiveness, ease of use and side effects. This tool may not cover all possible drug interactions. Handbook of drug interactions a clinical and forensic guide. Its used to treat airflow obstruction symptoms such as wheezing, shortness of breath, and chest. Pdf drug interactionsprinciples, examples and clinical. Drug interactions and adverse drug effects are responsible for the.
Pharmacokinetic drug interactions with theophylline. This study is created by ehealthme based on reports of 186 people who take levofloxacin and theophylline from food and drug administration fda, and is updated regularly. Subsequently theophylline concentrations were found to parallel a number of changes in fluvoxamine dosage see reference number 7. This document does not contain all possible drug interactions. These substances may show some reactions with theophylline. Theophylline is a bronchodilator that is used to treat symptoms of asthma, bronchitis, emphysema, and other breathing problems.